🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
Latent Space: The AI Engineer Podcast
- Published
- May 27, 2026
- Duration
- 1h 10m
- Summary source
- description
- Last updated
- Jul 5, 2026
Discusses Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of E…
Summary
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked o…
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Show notes
Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions of protein sequences drawn from across life, with a simple “next token” objective: predict the amino acids that have been randomly masked out, based on the context of the rest of the sequence. But they soon found that these models also learned biological structure and function, inc