Summary

Microsoft Copilot EVP Jacob Andreou joins to discuss the AI agent race as they release a new Copilot update today. Then, Guardant Health CEO Helmy Eltoukhy joins after the company received FDA approval for a blood test for breast cancer treatment guidance. Plus, we break down Costco's latest earnings, which have the stock heading higher today.Squawk on th…

Key takeaways

• Microsoft's Copilot reboot consolidates chat, coding (Code), and autonomous agents (Autopilot) into a single 'work OS,' shifting from flat subscription pricing to usage-based billing to monetize its 450M Office 365 seats—of which fewer than 7% currently pay for the AI add-on.
• Guardant Health's FDA-approved liquid biopsy blood test (Guardian 360 CDX) demonstrated a 56% reduction in risk of death and progression for metastatic breast cancer patients by enabling real-time molecular resistance monitoring every three months, with expansion to lung, pancreatic, and other cancers anticipated.
• Citi's Heath Terry argues that AI frontier labs are strategically using 'pacing' and national security framing to push regulators toward an even playing field with Chinese competitors, effectively lobbying against FINRA-style oversight boards while seeking liability protection similar to Section 230.

Why this matters

The convergence of enterprise AI agent platforms (Microsoft Copilot, Anthropic Claude, OpenAI), shifting usage-based monetization models, and unresolved regulatory and liability frameworks will fundamentally reshape B2B software procurement, cybersecurity spending, and competitive dynamics across financial services, healthcare diagnostics, and logistics over the next 12–24 months.

Entities

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Show notes

Microsoft Copilot EVP Jacob Andreou joins to discuss the AI agent race as they release a new Copilot update today. Then, Guardant Health CEO Helmy Eltoukhy joins after the company received FDA approval for a blood test for breast cancer treatment guidance. Plus, we break down Costco's latest earnings, which have the stock heading higher today.Squawk on the Street Disclaimer Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data

Themes

• agents
• investing