The a16z Show
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
All episodes(126)
- StandardSummaries onlyWhy a16z is Building a New School for the AI Era | Ben Horowitz
Published Sep 22, 2026
Ben HorowitzBen Horowitz and Erik Torenberg sit down with Gagan Biyani to introduce the Horowitz and Andreessen Academy and discuss a bigger question: what should education look like when AI is rapidly changing the skills people need to build, work, and create?Ben and Gagan explain why they believe learning should be more focused on doing rather than studying about doing, with students building real projects, developing people skills, and working alongside companies and builders in San Francisco. The goal i
- StandardSummaries onlyAI Safety Language Is Destroying the Debate | Steven Sinofsky
Published Sep 21, 2026
Steven Sinofskya16z Board Partner and former Microsoft Windows president Steven Sinofsky joins Theo Jaffee and Sofia Puccini on MTS to argue that the language we use to describe AI failures is making it harder to understand what’s actually going wrong.Steven takes aim at terms like “alignment,” “goal-seeking,” and “rogue agents,” arguing that they can anthropomorphize problems that software engineers have dealt with for decades. His framing is simpler: when software doesn’t do what it’s supposed to do, it has
- StandardSummaries onlyNas, Grandmaster Caz, Steve Stoute & Ben Horowitz on Paying Hip-Hop’s Pioneers Their Due
Published Sep 20, 2026
Ben Horowitz and Erik Torenberg sit down with Nas, Grandmaster Caz, and Steve Stoute for a conversation about the Paid in Full Foundation and its mission to recognize and support the pioneers who built hip-hop.Ben, Nas, and Steve share how the foundation began, why simply giving artists money wasn’t enough, and how the Hip Hop Grandmaster Awards became a way to pair financial support with the recognition many foundational artists never received. Caz brings the perspective of one of those pioneer
- StandardSummaries onlyWhat Makes a Consumer AI Product Stick? | Josh Elman
Published Sep 19, 2026
Josh Elmana16z Partner Josh Elman joins Ollie Forsyth on New Economies to discuss the next wave of consumer AI and what separates a product people try once from one that becomes part of their everyday lives.Josh argues that getting attention has actually become easier, but getting consumers to stick is harder than ever. He explains what he looks for in consumer products, why the best ones start with a narrow wedge and earn the right to do more, and why trust becomes increasingly important as AI agents gai
- StandardSummaries onlyDatabricks CEO on AI Pacing, Cyber Risk, and the Enterprise
Published Sep 18, 2026
Databricks co-founder and CEO Ali Ghodsi joins a16z General Partners Martin Casado and Sarah Wang for a conversation about AI risk, recursive self-improvement, cybersecurity, and what’s actually holding back enterprise adoption.Ali argues that today’s models are already capable enough to automate far more work than most companies are using them for. The bigger problem is context: models haven’t been in every meeting, don’t understand how decisions actually get made, and lack the institutional kn
- StandardSummaries onlyThe Next Frontier of AI Video Is Control
Published Sep 17, 2026
a16z General Partner Jennifer Li sits down with fal co-founder Gorkem Yurtseven and Head of Engineering Batuhan Taskaya to discuss what changes when generative video becomes fast enough to run in real time.They unpack the technical work behind H3 Max, fal’s post-trained version of MiniMax’s open-weight video model, and how combining model post-training with systems and hardware optimization significantly reduced generation time while maintaining quality. That speed has enabled experiments with c
- StandardSummaries onlyThe AI-Native CRM
Published Sep 16, 2026
a16z’s Alex Rampell and Joe Schmidt sit down with Lightfield co-founder and CEO Keith Peiris to discuss what it takes to rethink the CRM for an AI-native world, and the unusual pivot that got him there.Keith previously built Tome to 25 million users, but eventually walked away from the product after concluding that the underlying technology couldn’t capture enough context about a presenter, their audience, and the relationship between them. Starting again, his team followed customers from AI pre
- StandardSummaries onlyThe Age of Body Futurism | Ruby Justice Thelot
Published Sep 15, 2026
Ruby Justice ThelotElena Burger sits down with academic and cyber ethnographer Ruby Justice Thelot to explore the increasingly blurry line between internet culture and the real world, and how to tell the difference between a trend that’s actually changing behavior and one that simply feels enormous online.They use today’s wellness and optimization culture as a case study, from peptides and GLP-1s to protein maxxing, wearables, microplastics, and the quantified self. Ruby explains her concept of “paracontent,” wher
- StandardSummaries onlyGreg Brockman on Why OpenAI Says We’re Entering the AGI Era
Published Sep 14, 2026
Ben Horowitz and Erik Torenberg sit down with OpenAI co-founder and President Greg Brockman to discuss why he believes AI has entered a new phase, what OpenAI’s latest models reveal about the path to AGI, and the safety and security challenges that come with increasingly capable systems.Greg explains why computer use represents such an important step for agents, including models that can work coherently for 24 hours and interact with software through the same interfaces humans use. He also share
- StandardSummaries onlyWorld Models, Robotics, and the Future of 3D AI
Published Sep 13, 2026
World Labs co-founder Justin Johnson joins MTS hosts Theo Jaffee and Sofia Puccini to discuss Atlas, World Labs’ latest world model, and the broader case for AI systems that understand and interact with the physical world.Justin explains how Atlas approaches three core tasks: generating new worlds, reconstructing real environments from images, and simulating how objects or robots might behave within them. Underlying it is a bigger thesis: just as language models became general-purpose engines fo
- StandardSummaries onlyWhy Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast
Published Sep 12, 2026
a16z General Partner Anish Acharya joins Lenny Rachitsky on Lenny’s Podcast to discuss why fears of an AI-driven “permanent underclass” may be misplaced, how AI is changing the way companies operate, and why the opportunity may be less about replacing people and more about dramatically expanding what they can build.Anish lays out his idea that companies are becoming a series of loops, with agents increasingly handling workflows across engineering, sales, marketing, support, and other functions w
- StandardSummaries onlyWhat It Takes to Build a Startup | Andrew Chen & Matt Perault
Published Sep 11, 2026
a16z’s Matt Perault sits down with General Partner and Speedrun lead Andrew Chen on the a16z AI Policy Brief to explore what “Little Tech” actually looks like at the earliest stages, and why the realities of building a two- or three-person startup are often missing from policy debates.Andrew takes us inside Speedrun, where founders are often starting companies from kitchen tables, working with tiny teams, and trying to determine in a matter of months whether their idea can become a viable busine
- StandardSummaries onlyHow AI Is Rewriting the Power Law of Venture Capital
Published Sep 10, 2026
a16z’s Jen Kha and David George sit down with Accolade Partners’ Aram Verdiyan to discuss how AI is changing the power law of technology investing, why the largest companies can compound advantages in ways that weren’t possible before, and what that means for how investors construct portfolios.They explore why AI may be much bigger than traditional software, with applications reaching into labor, healthcare, transportation, services, and other major parts of the economy. David explains why capit
- StandardSummaries onlyWho Grades the AI Models? | Ben Horowitz & Rayan Krishnan
Published Sep 9, 2026
a16z’s Erik Torenberg, Ben Horowitz, and Jennifer Li sit down with Vals founder and CEO Rayan Krishnan to discuss one of AI’s increasingly difficult problems: how do you actually measure whether a model is getting better?As public benchmarks saturate and models get better at optimizing for the tests themselves, Rayan makes the case for independent, continuously evolving evaluations. They unpack why self-reported model scores can be misleading, how VALS evaluates models in the hours before a rele
- StandardSummaries onlyOpenAI Researchers on the Future of Mathematical Reasoning
Published Sep 8, 2026
a16z Infra Partner Lisha Li sits down with OpenAI mathematicians Mehtaab Sawhney and Mark Sellke to discuss how quickly AI’s mathematical capabilities are advancing, what recent results reveal about model reasoning, and what happens when AI begins making progress on problems mathematicians have struggled with for decades.Mehtaab and Mark unpack several recent results from OpenAI’s models, including advances in sphere packing and the construction of a non-sofic group. They explain why the surpris
- StandardSummaries onlyCan Open Source Keep AI Power From Concentrating?
Published Sep 7, 2026
MTS host Sophia Dew visits the Open Source AI Summit in San Francisco to ask researchers and founders across the AI stack a central question: can open source prevent AI power from concentrating in the hands of a few companies?Lukasz Kaiser, co-author of Attention Is All You Need, argues that today’s concentration may be a feature of the current technological paradigm rather than a permanent feature of AI. Transformers reward enormous amounts of data and compute, but future breakthroughs could ma
- StandardSummaries onlyYour AI Doctor Is Coming | Julie Yoo
Published Sep 6, 2026
Julie Yooa16z General Partner Julie Yoo joins MTS host Sophia Dew to explain why she believes healthcare could benefit more from AI than almost any other industry, and why decades of slow technology adoption may actually give healthcare an advantage in the AI era.Julie traces healthcare’s evolution from paper records and fax machines through electronic health records and telehealth, and explains why AI represents something different: an organic adoption wave driven by tools that doctors and patients actu
- StandardSummaries onlyAaron Levie on Why Open AI Wins
Published Sep 5, 2026
Box co-founder and CEO Aaron Levie joins MTS hosts Theo Jaffee and Sofia Puccini to make the case for open-weight AI, unpack the economics of open versus closed models, and explain why he believes more openness could strengthen rather than undermine the U.S. AI ecosystem.Aaron argues that open models create more use cases, push closed labs to innovate faster, and don't fundamentally change where the economics of AI ultimately accrue. They debate model distillation, America's competition with Chi
- StandardSummaries onlyFei Fei Li: The Race to Build World Models For AI
Published Sep 4, 2026
Fei Fei LiWorld Labs co-founders Fei-Fei Li, Justin Johnson, and Ben Mildenhall join a16z General Partner Martin Casado to discuss Atlas, their latest world model, and what it reveals about the pursuit of spatial intelligence.At the center of Atlas is what the team calls “new view prediction”: given images or views of a scene, the model predicts what that environment should look like from a different position in space and time. This brings generation and 3D reconstruction into the same model, and raises a
- StandardSummaries onlyThe $100B Niches Hiding Inside Payments
Published Sep 3, 2026
Erik Torenberg is joined by a16z General Partner Alex Rampell and Affirm Co-Founder and CEO Max Levchin for a conversation on 25 years of fintech, from the early days of digital payments to the origins of Affirm and the next generation of agentic commerce.Max and Alex revisit what surprised them most about how payments evolved, why the card interface has been so difficult to displace, and why even the smallest corners of payments can become enormous markets. They also trace the early idea maze b
- StandardSummaries onlyInside Moderna’s Personalized Cancer Vaccine
Published Sep 2, 2026
a16z General Partner Jorge Conde sits down with Moderna CEO Stéphane Bancel to discuss a major milestone for mRNA technology: positive Phase 3 results from Moderna and Merck’s individualized treatment for melanoma, after more than a decade of work on personalized cancer vaccines. Stéphane explains how the treatment works by sequencing an individual patient’s tumor and healthy cells, identifying the mutations most relevant to their cancer, and encoding up to 34 of them into an mRNA designed speci
- StandardSummaries onlyDaniel Litt: The Mathematician's Guide to AI
Published Sep 1, 2026
Daniel Litta16z’s Lisha Li sits down with Daniel Litt, Assistant Professor of Mathematics at the University of Toronto, to unpack AI's rapid progress in mathematics, what today's frontier models can actually do, and what they're still missing about the way mathematicians think. Daniel explains why some recent AI-generated results are genuinely impressive, including an autonomous solution to the Erdős unit distance problem, but argues that solving problems is only one part of mathematics. Today's models can
- StandardSummaries onlyGavin Baker: Why AI Demand Is Outrunning Compute Supply
Published Aug 31, 2026
Gavin Bakera16z’s David George sits down with Gavin Baker to unpack the state of the AI boom, why demand for intelligence may still be dramatically underestimated, and why the outcome doesn't necessarily have to be winner-take-all. David and Gavin explore the possibility that frontier labs, open-source models, applications, clouds, and NVIDIA can all capture significant value as AI adoption expands. They dig into the economics of the infrastructure buildout, why compute investments can have unusually fast
- StandardSummaries onlyWhy a16z Launched the Machine Age Fund | Jen Kha
Published Aug 30, 2026
Jen Khaa16z Managing Partner and Head of Global Partnerships Jen Kha joins MTS hosts Theo Jaffee and Sophia Dew to discuss a16z's Machine Age Fund and the investment thesis behind rebuilding the physical infrastructure that powers AI. Jen explains why chips, networking, memory, cooling, data centers, and other parts of the physical computing stack are becoming investable again after decades in which software captured much of the industry's attention. As AI demand pushes existing infrastructure to its l
- StandardSummaries onlyWhy 1,200 AI Agents Started Working Together | Ryan Greenblatt
Published Aug 29, 2026
Ryan GreenblattRyan Greenblatt, Chief Scientist at Redwood Research, joins MTS host Theo Jaffee to unpack a new independent investigation into the OpenAI Hugging Face hacking incident and what it reveals about how large groups of AI agents behave when they're allowed to coordinate. Ryan and his collaborators found agents spontaneously organizing through message boards, sharing information, assigning tasks, forming teams, and even sacrificing their own chances of success to help other agents. Rather than simply
- StandardSummaries onlyThe Infrastructure Behind the Machine Age
Published Aug 28, 2026
Ben Horowitz, Martin Casado, Raghu Raghuram, and Erik Torenberg discuss the launch of a16z's new Machine Age Fund and the infrastructure buildout behind AI, from chips, memory, and networking to power, cooling, and data centers. Why a dedicated fund now? The group argues that the bottleneck in AI is increasingly shifting from the models themselves to everything beneath them. Hyperscaler CapEx is surging, critical components are booked years in advance, and each new generation of reasoning and ag
- StandardSummaries onlyInside Cursor: The Anatomy of a Generational Startup
Published Aug 27, 2026
Inside Cursora16z General Partners Martin Casado, Sarah Wang, and Matt Bornstein unpack the story of Cursor: how a small, product-obsessed team entered one of the most competitive markets in technology, took on incumbents with seemingly unbeatable advantages, and repeatedly made decisions that ran against conventional startup wisdom. They revisit the early bet that the interface between humans and AI would matter more than building a coding-specific foundation model, why Cursor built its own product rather t
- StandardSummaries onlyThe State of AI: Macro, Apps, and Consumer
Published Aug 26, 2026
Anish Acharya joins Jen Kha to break down the next frontier of AI, from the evolving model landscape and open-source AI to why the application layer, and consumer AI in particular, may be entering a new phase. Anish explains why he believes there will be multiple winners at the model layer, why traditional moats like network effects, scale, and brand still matter, and how companies can choose between frontier and open-weight models depending on the economics of the task. They also explore why mo
- StandardSummaries onlyThe New Economics of AI | Martin Casado & Steven Sinofsky
Published Aug 25, 2026
a16z General Partners Martin Casado and Erik Torenberg are joined by Board Partner Steven Sinofsky to explore what recent breakthroughs in AI and mathematics tell us about where the technology is headed, and whether some of the basic assumptions that have governed computing for decades are starting to break. Martin and Steven debate whether AI's progress in mathematics represents a genuine leap in reasoning or simply a new tool for solving problems at a higher level of abstraction. From the four
- StandardSummaries onlyWhy Medical AI Needs a Referee | Protege's Engy Ziedan
Published Aug 24, 2026
Daisy Wolf and Eva Steinman are joined by Engy Ziedan, co-founder and Chief Scientific Officer of Protege, to discuss why medical AI has a measurement problem, and why scoring well on a benchmark doesn't necessarily mean a model is ready for the hospital. Engy explains why healthcare AI needs independent evaluations that go beyond static exams and measure how models actually perform in real-world clinical workflows. They explore the risks of subtle bias and misalignment, why the same model can r
- StandardSummaries onlyMartin Casado on Where the Value Is Going in AI
Published Aug 22, 2026
Martin Casado joins MTS hosts Theo Jaffee and Sophia Dew to unpack where value is actually accruing in AI, why this technology cycle looks fundamentally different from previous waves, and whether the frontier labs will ultimately capture most of the market. Martin explains why AI has turned venture into a scale-up capital game, where small teams can productively deploy extraordinary amounts of money, and why the relationship between capital, innovation, and growth has never been tighter. He lays
- StandardSummaries onlyHow Microsoft Is Securing the Agentic Enterprise | Aaron Zollman
Published Aug 21, 2026
Aaron Zollmana16z's Joel De La Garza is joined by Aaron Zollman, Deputy CISO at Microsoft Gaming, to discuss how security teams can embrace AI agents without losing control. Aaron shares Microsoft's experience with OpenClaw, from the initial instinct to ban it to figuring out how to make it safe to use. They unpack what agents mean for identity, permissions, containerization, and monitoring, as well as how AI is shifting the CISO's role from saying "no" to safely enabling new technology. They also explore wh
- StandardSummaries onlyHow Global Networks Are Reshaping Startup Success
Published Aug 20, 2026
Elena Burger is joined by a16z’s Angela Strange and Gabriel Vasquez to discuss the rise of the "borderless founder": entrepreneurs who bring the networks and insights of their home markets together with the talent, capital, and speed of Silicon Valley to build global companies. Angela and Gabriel trace how a16z's international investing efforts grew from early work in Latin America into a broader global network, and why AI has accelerated the flow of founders and talent between Silicon Valley an
- StandardSummaries onlyHow Whatnot Built a Global Marketplace
Published Aug 19, 2026
a16z General Partner David George is joined by Grant LaFontaine, co-founder of Whatnot, to unpack how a marketplace that started with collectibles evolved into one of the world's leading live shopping platforms. Grant traces the company's origins from selling Pokémon cards online as a kid to discovering live commerce by watching Whatnot's earliest customers hack together sales on social media. They discuss why Whatnot thinks less like a traditional e-commerce marketplace and more like a digital
- StandardSummaries onlyHow Do You Defend Against AI That Can Hack?
Published Aug 18, 2026
a16z's Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend against humans and malware suddenly have to contend with AI agents. As frontier models become more capable of finding and exploiting vulnerabilities, many of the assumptions underlying traditional security are beginning to break. They explore why guardrails designed to stop AI-powered attackers can also prevent security teams from doing their jobs, wh
- StandardSummaries onlyStripe’s AI Strategy: Build More, Not Less
Published Aug 17, 2026
a16z General Partner David George is joined by Will Gaybrick, President of Product & Business at Stripe, to discuss how AI is changing the way Stripe builds products, organizes teams, and thinks about the future of internet commerce. Stripe has evolved from a payments company into a multi-product financial infrastructure platform, while a new generation of AI companies is growing and monetizing faster than previous software cohorts. Will explains why Stripe sees AI productivity as an opportunity
- StandardSummaries onlyBen Horowitz and Travis Kalanick on Building Again
Published Aug 14, 2026
Ben Horowitz, Travis Kalanick, and Erik Torenberg take the stage at Atoms' launch event for a candid fireside conversation about entrepreneurship, company building, and why Kalanick believes the next industrial revolution will be powered by AI. They revisit pivotal moments from Uber's history, including the decision not to acquire Lyft, lessons from scaling one of the world's fastest-growing companies, and how Kalanick has evolved as a founder. The conversation also explores Atoms' vision for in
- StandardSummaries onlyThe Two Ways to Sell AI: Lighthouse or Landgrab?
Published Aug 13, 2026
Elena Burger is joined by a16z's Andy McCall and Joe Schmidt to break down two very different ways AI startups can go to market: the lighthouse and the landgrab. Should founders win a handful of marquee customers whose credibility unlocks an entire industry, or move quickly across a broad market where the ROI already speaks for itself? Drawing on Joe's Lighthouse or Landgrab framework and Andy's experience building sales organizations at Samsara and Meraki, they explore how founders can determin
- StandardSummaries onlyGarry Tan on Taste, Agents and Founder Ambition
Published Aug 12, 2026
Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founders should be more ambitious than ever, and what two decades of Silicon Valley booms, busts, and missed opportunities have taught Garry about building what's next. Garry reflects on turning down an early opportunity to join Palantir, why chasing what's "hot" is often the wrong strategy, and why the best ideas tend to begin with people pursuing stran
- StandardSummaries onlyThe CISO Playbook for AI Agents | Datadog
Published Aug 11, 2026
a16z's Joel De La Garza is joined by Emilio Escobar, Chief Information Security Officer at Datadog, to discuss what it takes to secure a company where nearly every employee is using AI and more than 4,000 engineers are working with coding agents. Rather than trying to block new tools, Emilio explains why Datadog chose to embrace AI early and build the security infrastructure needed to use it safely. They unpack how AI changes traditional assumptions around data permissions, credentials, develope
- StandardSummaries onlyHow Kavak Rebuilt Itself Around AI Agents | Alejandro Maza Ayala
Published Aug 10, 2026
Alejandro Maza AyalaAngela Strange and Gabriel Vasquez are joined by Alejandro Maza Ayala, Chief Product & AI Officer at Kavak, to unpack how the Latin American used-car marketplace rebuilt itself around AI agents, with 96% of customer interactions and 95% of transactions now handled by agents. Alejandro explains why Kavak decided that simply giving employees AI tools wasn't enough, and instead redesigned the company's systems, teams, and customer experience around agents. They discuss why Kavak spends as much engi
- StandardSummaries onlyThe Reality of AI-Powered Cyberattacks | Truffle Security & Socket
Published Aug 7, 2026
Joel De La Garza is joined by Dylan Ayrey, co-founder and CEO of Truffle Security, and Feross Aboukhadijeh, founder and CEO of Socket, to discuss one of the biggest shifts happening in cybersecurity: AI models are no longer just finding vulnerabilities—they're exploiting them. As frontier models become increasingly capable of hacking, software security, supply chain attacks, and cyber defense are entering a fundamentally new era. The conversation explores AI-powered hacking, software supply chai
- StandardSummaries onlyHow Open-Source AI Became Critical Infrastructure
Published Aug 6, 2026
Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today's most advanced AI applications. Together, they explore how open-source AI evolved from a research project into critical infrastructure, why inference has become one of the most important layers of the AI stack, and what it takes to bring frontier intelligence to developers around the world. The conversation covers vLLM's origins, the rise of open-weight
- StandardSummaries onlyThree Startups Reinventing Critical Infrastructure
Published Aug 5, 2026
This week, a16z American Dynamism Films premiered three short documentaries highlighting companies tackling some of America's biggest industrial challenges: Ulysses, Mariana Materials, and Radiant. Before watching those films, we're revisiting conversations with the founders behind each company. You'll hear Will O'Brien explain why autonomous underwater robots could unlock a new era of ocean exploration and security, Turner Caldwell discuss rebuilding America's critical minerals supply chain and
- StandardSummaries onlyOpenAI's Joshua Achiam: Did We Already Reach AGI?
Published Aug 4, 2026
Theo Jaffee is joined by Joshua Achiam, Chief Futurist at OpenAI, for a conversation on AI cybersecurity, frontier model capabilities, and why he believes society may have already crossed the threshold into an AGI-era without fully recognizing it. They discuss AI's rapidly advancing cyber capabilities, state-sponsored hacking, model jailbreaks, recursive self-improvement, and what happens when AI systems begin discovering vulnerabilities faster than humans can patch them. Joshua also explains wh
- StandardSummaries onlyRuby Thelot on Internet Culture, AI, and the Future of Taste
Published Aug 2, 2026
Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ranging conversation about internet culture, AI, digital communities, and how technology is reshaping the way we relate to one another. Drawing on years of research into online behavior, Ruby explains how digital cultures form, why algorithms shape more than just what we see, and what AI is changing about creativity, communication, and identity. They
- StandardSummaries onlyMarc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation
Published Aug 1, 2026
Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for comprehensive U.S. market structure legislation and what regulatory clarity could mean for innovation, financial markets, and America's technological leadership. They explore the CLARITY Act, stablecoins, securities law, consumer protection, and why both builders and financial institutions are calling for clear rules of the road. Along the way, they discu
- StandardSummaries onlyDecagon’s Playbook for Building Enterprise AI Applications
Published Jul 31, 2026
Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents, why the company increasingly relies on open-source models, and how it is helping some of the world’s largest companies deploy AI in production. Decagon has become one of the fastest-growing AI companies by building agents that automate customer support, sales, and operational workflows. Jesse, Decagon’s CEO, and Ashwin, its president, explain how t
- StandardSummaries onlyAI for America's Small Businesses | Lassie
Published Jul 30, 2026
Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of the economy: small businesses. Inspired by time spent working inside dental practices, Pelle and Renken set out to automate the administrative work that keeps healthcare providers away from patients. They discuss how AI agents are changing billing, insurance claims, patient payments, and other operational workflows, allowing practices to spend less
- StandardSummaries onlyAI Micro Dramas, Generative Media, and the Future of Creativity
Published Jul 29, 2026
Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is reaching an inflection point. They discuss the rise of AI micro-dramas, how creators are building entirely new forms of entertainment, and why the biggest opportunities may lie not in replacing Hollywood—but in expanding who gets to create. They also cover the future of creator tools, AI agents for individuals, generative video, AI "slop," the economi
- StandardSummaries onlyFei-Fei Li on Spatial Intelligence and Robotics
Published Jul 28, 2026
Last week, World Labs announced its acquisition of SceniX, bringing together two teams working on one of AI's biggest unsolved problems: how to give machines a true understanding of the physical world. Martin Casado sits down with Fei-Fei Li, co-founder and CEO of World Labs, creator of ImageNet, and pioneer of spatial intelligence, alongside Yunzhu Li, co-founder of SceniX and assistant professor at Columbia University. They discuss why World Labs acquired SceniX, how simulation can unlock the
- StandardSummaries onlySteven Sinofsky: AI Doesn't Need New Rules Yet
Published Jul 27, 2026
Steven SinofskySteven Sinofsky joins Theo Jaffee and Sofia Puccini for a conversation on AI regulation, open-source models, and what history can teach us about technological revolutions. Drawing on decades of experience leading products at Microsoft, Sinofsky argues that governments are rushing to regulate AI before they fully understand the technology, risking innovation in the process. They discuss the "precautionary principle," why open source has historically accelerated innovation, the role of regulation
- StandardSummaries onlyBen Horowitz: The Fight Over Open Source AI
Published Jul 26, 2026
Ben HorowitzBen Horowitz joins Theo Jaffee and Sofia Puccini to discuss one of the biggest debates in AI today: the future of open-source models. They examine the growing push to restrict open models, why Ben believes open source is critical for security, innovation, and competition, and what happens if a handful of frontier labs come to dominate the AI ecosystem. They also discuss distillation, AI monopolies, China's role in open-source AI, robotics, manufacturing, the economics of frontier models, and why
- StandardSummaries onlySriram Krishnan on Open Source AI's Biggest Week Yet
Published Jul 24, 2026
Sriram Krishnan joins Theo Jaffee and Sofia Puccini just after concluding his tenure as Senior White House Policy Advisor on AI to discuss one of the biggest weeks yet for open-source AI. They unpack the rapid release of models including Kimi K3 and Qwen, why open models are putting pressure on frontier labs, and what it means for pricing, competition, and the future of AI infrastructure. They also discuss AI policy, distillation, cybersecurity, the role of open-weight models, whether the U.S. s
- StandardSummaries onlyBuilding the Physical AI Stack | Travis Kalanick on TBPN
Published Jul 23, 2026
Travis Kalanick joins TBPN to discuss Atoms, his vision for industrial AI, and why he believes the biggest opportunities in AI lie beyond software. He explains how Atoms is bringing autonomy to mining, logistics, and food production, why robotics will reshape physical industries, and how lower costs and greater automation could unlock entirely new economic opportunities. Travis also reflects on raising $1.7 billion, building in stealth, regulation, hiring, and what he's learned since Uber. Resou
- StandardSummaries onlyTravis Kalanick Is Back | Building the Future of Industrial AI
Published Jul 22, 2026
Travis Kalanick, Ben Horowitz, and Erik Torenberg reunite to reflect on Uber's early days, the investment that almost happened, and why Kalanick believes the next great technology opportunity lies beyond software. They discuss the lessons of building Uber, the value of founder-led companies, and why Kalanick spent nearly eight years quietly building Atoms before stepping back into the spotlight. The conversation explores industrial AI, robotics, autonomy, mining, food production, and Kalanick's
- StandardSummaries onlyWhy Physical AI Is the Next Frontier | Applied Intuition
Published Jul 21, 2026
Applied IntuitionApplied Intuition has spent the past decade building the software that powers intelligent machines, from passenger vehicles and trucks to defense systems, mining equipment, and industrial robots. In this conversation, Marc Andreessen and Erik Torenberg sit down with Applied Intuition cofounders Qasar Younis and Peter Ludwig to discuss the emergence of physical AI and the company's latest launch, Dana, a new platform designed to accelerate the development of autonomous systems. They explore auton
- StandardSummaries onlyHugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition
Published Jul 20, 2026
As governments weigh new restrictions on frontier AI models, one question is becoming increasingly important: what role should open source play in the future of artificial intelligence? Theo Jaffee and Sofia Puccini speak with Hugging Face CEO Clément Delangue about AI regulation, open source safety, model routing, and why he believes competition—not consolidation—is essential for the industry's future. They discuss GPT-5, government oversight of frontier models, Hugging Face surpassing $100 mil
- StandardSummaries onlyAmjad Masad on Going Direct, Building Replit, and the Future of Software
Published Jul 17, 2026
Recorded live at the New Media Summit, Erik Torenberg sits down with Replit founder and CEO Amjad Masad to discuss founder-led storytelling, building in public, and the role of media in company building. Masad reflects on Replit’s decade-long journey, including the years before the company’s recent breakout growth, and explains why communicating a vision can be just as important as executing on it. He argues that for many founders, especially those building ambitious products ahead of the market
- StandardSummaries onlyReplay 2025: David Sacks on AI, Crypto, and America's Technology Future
Published Jul 16, 2026
As part of our summer replay series, we're revisiting one of our most-discussed conversations from the past year. David Sacks joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to discuss the intersection of AI, crypto, regulation, and American competitiveness. The conversation explores the Trump administration's approach to AI and crypto policy, open source AI, export controls, energy and infrastructure, the global race with China, and the role regulation plays in shaping innovation. They
- StandardSummaries onlyCan Anyone Catch NVIDIA? | The Future of Chips and Infrastructure
Published Jul 15, 2026
As part of our summer replay series, we're revisiting one of our favorite conversations on the future of AI infrastructure. SemiAnalysis founder Dylan Patel joins Erin Price-Wright, Guido Appenzeller, and Erik Torenberg to examine the rapidly evolving economics of AI hardware, from GPUs and custom silicon to data centers, power, and the global race for compute. The conversation explores NVIDIA's competitive advantages, the rise of custom chips from Google, Amazon, and Meta, the economics of fron
- StandardSummaries onlyIs AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy
Published Jul 14, 2026
As part of our summer replay series, we're revisiting one of the standout conversations from Runtime, a16z's conference on AI infrastructure and the future of computing. Gavin Baker, Managing Partner and CIO of Atreides Management, joins David George to examine the biggest questions surrounding today's AI investment cycle. Is AI a bubble? What does the unprecedented buildout of data centers, GPUs, and compute infrastructure mean for the economy? And how should investors think about the companies
- StandardSummaries onlyBefore Blockchains, There Was State Machine Replication
Published Jul 13, 2026
Every blockchain today relies on replication techniques first developed in the 1980s by researchers who weren't thinking about cryptocurrencies at all. In this episode, Tim Roughgarden speaks with MIT professor and Turing Award winner Barbara Liskov, one of the pioneers of programming languages, fault tolerance, and distributed systems. Joined by a16z crypto research partner Ittai Abraham, they trace the evolution of ideas that now underpin modern blockchain networks. The conversation explores v
- StandardSummaries onlyHow Bitcoin Rewired a Classic Computer Science Problem
Published Jul 10, 2026
We're excited to share a special feed drop from The a16z Crypto Show. In the first episode of First Principles: The Scientific Roots of Blockchain Technology, Tim Roughgarden and Ittai Abraham trace the decades of computer science research that laid the foundation for modern blockchains. Long before Bitcoin, researchers were studying one of distributed computing's hardest challenges: how independent machines can reliably agree on a shared state, even when some participants are faulty or maliciou
- StandardSummaries onlyMark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease
Published Jul 9, 2026
As part of our summer replay series, we're revisiting one of our favorite conversations from the past year. Mark Zuckerberg and Dr. Priscilla Chan join Ben Horowitz, Vineeta Agarwala, and Erik Torenberg to discuss the Chan Zuckerberg Initiative's ambitious effort to help cure, prevent, and manage disease by the end of the century. Rather than funding individual breakthroughs, CZI is focused on building the tools and infrastructure that can accelerate scientific discovery across entire fields. Th
- StandardSummaries onlyAdam Neumann: This Is How You Build Iconic Companies
Published Jul 8, 2026
Adam NeumannAdam Neumann joins Marc Andreessen, Ben Horowitz, and Erik Torenberg for a candid conversation about entrepreneurship, failure, and building Flow. Neumann reflects on his childhood, military service, immigration to the United States, the rise and fall of WeWork, and what he learned from one of the most scrutinized founder journeys in technology. He explains why Flow is focused on rethinking housing, community, and belonging, and why he believes technology can fundamentally improve how people liv
- StandardSummaries onlyIs Software Losing Its Head?
Published Jul 7, 2026
Seema Amble, Steven Sinofsky, and Elena Burger unpack one of the biggest questions facing enterprise software: what happens when AI agents become the primary users of software instead of humans? The conversation explores the rise of "headless" software, why APIs and agentic workflows are reshaping enterprise applications, and whether traditional SaaS products are becoming systems of record rather than systems of engagement. They discuss Salesforce's Headless 360 announcement, MCP, enterprise sof
- StandardSummaries onlyDon’t Follow Your Passion | Ben Horowitz’s Advice for New Graduates
Published Jul 6, 2026
In this commencement address to Columbia University's Fu Foundation School of Engineering and Applied Science Class of 2015, Ben Horowitz challenges some of the most common advice given to graduates. Rather than urging students to “follow their passion,” Horowitz argues that people should focus on developing their strengths and making meaningful contributions to the world. Drawing on stories from his own time at Columbia, the founding of technology companies, and investments in startups like Air
- StandardSummaries onlyTechnology, Alliances, and American Leadership.
Published Jul 3, 2026
Ben Horowitz is joined by Anne Neuberger, Raghu Raghuram, and Jen Kha to discuss a16z's expanding international strategy and the growing role technology plays in economic growth, national security, and global partnerships. The conversation explores why America's technology leadership matters beyond Silicon Valley, how AI is reshaping relationships between governments and the private sector, and why countries around the world are looking to adopt frontier technologies while building stronger inno
- StandardSummaries onlyOutsmarting Uber: Why Bolt Wins in Europe
Published Jul 2, 2026
Outsmarting UberWhat does it take to build a global mobility company from a country of just 1.3 million people? Markus Villig, founder and CEO of Bolt, joins the show to share how he scaled from Estonia to 50+ countries, navigating early scrappy days, a near-bankruptcy from expanding too fast, and the hard-won lessons behind Bolt’s capital-efficient growth. They also discuss building in Europe vs. the U.S., competing against much better-funded rivals, and why culture and ambition matter more than regulation. Fi
- StandardSummaries onlyRick Rubin on AI, Creativity, and The Way of Code
Published Jul 1, 2026
Rick Rubin joins Marc Andreessen, Ben Horowitz, Anjney Midha, and Erik Torenberg to discuss creativity, artificial intelligence, and his book The Way of Code, which reimagines the Tao Te Ching for the age of AI. The conversation explores vibe coding, remix culture, artistic process, entrepreneurship, and what AI changes, and doesn't change, about creativity. Rubin argues that AI is best understood not as a replacement for artists, but as another creative tool, one that expands what's possible wh
- StandardSummaries onlyBuilding AI for Creators | Luma & Phota Labs
Published Jun 30, 2026
Yoko Li speaks with Luma's Head of Applied Research Matt Tancik and Phota Labs cofounder and CTO Zach Xia about how AI is changing creativity, photography, and the tools people use to make art. The conversation explores the evolving relationship between artists and AI, from image generation and personalization to creative workflows, controllability, and agentic design tools. They discuss personalization, photography, creative software, model design, evaluation, and why the future of creative too
- StandardSummaries onlyBeyond P(doom): Marc Andreessen - Betting on America
Published Jun 29, 2026
Marc Andreessen joins CSIS's Navin Girishankar for a wide-ranging conversation on artificial intelligence, productivity growth, industrial policy, and America's technological future. Andreessen argues that while AI has already begun reshaping the economy, the largest impacts are still ahead. He explores how AI could dramatically expand access to expertise, improve productivity, and transform industries ranging from healthcare and education to law and software development. At the same time, he wa
- StandardSummaries onlyAI Is Crossing the Frontier of Human Knowledge | Kevin Weil
Published Jun 26, 2026
Kevin WeilKevin Weil, the previous CPO & Vice President of Science at OpenAI, joins Speedrun to discuss the future of AI, scientific discovery, and startup building. After helping build products at Twitter, Instagram, and Facebook, Weil is now focused on one of AI's most ambitious applications: accelerating science itself. He explains why modern AI models are beginning to solve problems that sit beyond the frontier of existing human knowledge, and how advances in reasoning, coding, and autonomous research
- StandardSummaries onlyMarc Andreessen on AI, Technology, and the Future of Humanity
Published Jun 25, 2026
Michael Malice sits down with Marc Andreessen to discuss artificial intelligence, technological progress, economic growth, and the future of human flourishing. Drawing on decades of experience spanning the birth of the commercial internet through today’s AI boom, Andreessen argues that many of the most common fears about technology are rooted in a misunderstanding of how innovation creates opportunity. He explains how modern AI systems work, why large language models differ from earlier visions
- StandardSummaries onlyWhat Happens to Design After AI?
Published Jun 24, 2026
Anish Acharya speaks with Microsoft VP of Design John Maeda and Impeccable founder and CEO Paul Bakaus about how AI is changing the practice of design. The conversation explores the relationship between design and technology, the rise of AI-powered creative tools, and whether automation raises the floor, the ceiling, or both. Maeda and Bakaus discuss software craftsmanship, taste, creative judgment, and why some aspects of design may become increasingly automated while others become more valuabl
- StandardSummaries onlyWhat’s Next for Consumer AI? | Josh Elman Joins a16z
Published Jun 23, 2026
Anish Acharya sits down with Josh Elman to discuss the future of consumer technology and Josh's decision to join a16z. Over the past two decades, Elman has helped shape some of the most important consumer technology products and companies, including LinkedIn, Facebook, Twitter, Robinhood, Discord, Musical.ly, TikTok, and Apple. Drawing on those experiences, he reflects on how technology has evolved from a niche industry into a central force in everyday life. The conversation explores consumer AI
- StandardSummaries onlyJake Paul & Anti Fund: From Creator to Investor
Published Jun 22, 2026
Jake Paul and Geoff Woo join the podcast to announce Anti Fund’s new $100 million growth fund and discuss the evolution of their investment strategy. The conversation covers the fund’s portfolio, including investments in companies such as SpaceX, OpenAI, Anthropic, Anduril, Cognition, Etched, and Modal, as well as the lessons they’ve learned backing founders and identifying emerging technologies. They discuss founder psychology, resilience, ambition, and why they believe attention, culture, and
- StandardSummaries onlyThe New Rules of Media | Marc Andreessen & Ben Horowitz
Published Jun 19, 2026
Recorded live at the New Media Summit, Marc Andreessen, Ben Horowitz, Erik Torenberg, and Gaby Goldberg discuss how media, communication, and influence are changing in the internet era. The conversation explores the shift from legacy media to creator-led platforms, why authenticity has become a competitive advantage, and how founders can build audiences by communicating directly with customers, employees, and the public. They discuss podcasts, social media, storytelling, corporate communications
- StandardSummaries onlyThe Fintech Playbook for Latin America
Published Jun 17, 2026
Angela Strange and Gabriel Vásquez speak with Addi founder and CEO Santiago Suárez about building one of Latin America's largest financial platforms. What began as a buy now, pay later product has evolved into a broader ecosystem spanning payments, commerce, logistics, and now banking. Serving millions of consumers and tens of thousands of merchants, Addi sits at the intersection of financial services and commerce in Colombia. The conversation covers building in Latin America, lessons from scali
- StandardSummaries onlyJack Altman on Product-Market Fit
Published Jun 16, 2026
Jack Altman joins Speedrun to discuss product-market fit, customer feedback, hiring, fundraising, and the realities of building an enduring company. Drawing on his experience building Lattice from startup to multi-billion-dollar company, Altman explains how founders should think about customer requests, when to pivot, and why some of the hardest decisions come from balancing conviction with market feedback. He shares lessons from the early days of Lattice, including finding product-market fit, b
- StandardSummaries onlyAI, Design, and the Power of Open Models
Published Jun 15, 2026
Yoko Li and Justine Moore speak with Ideogram founder and CEO Mohammad Norouzi about image generation models, design workflows, and the evolving relationship between AI and creative work. The conversation covers Ideogram's decision to release an open-weight model, the challenges of generating text and layouts within images, and why controllability has become an increasingly important area of research. They discuss prompting, customization, editing, and the tradeoffs between general-purpose model
- StandardSummaries onlySamo Burja on Growth, Energy, and AI
Published Jun 12, 2026
Theo Jaffee speaks with Samo Burja, founder of Bismarck Analysis, about AI, industrial capacity, economic growth, and the institutions that shape civilization. The conversation explores how AI’s demand for compute, energy, and infrastructure could trigger a new wave of industrial expansion, benefiting sectors far beyond technology. Burja argues that AI is not just a software story but a demand shock that will ripple through energy, manufacturing, construction, and global supply chains. They also
- StandardSummaries onlyDesigning the Physical World with AI
Published Jun 11, 2026
Erin Price-Wright speaks with Alex Modon, cofounder and CEO at Unlimited Industries, and Davide Asnaghi, CEO at Diode Computers, about how AI is moving from software into the physical world. They discuss automating construction and electronics design, using code and simulation to model real-world systems, and how incentives and manufacturing constraints shape adoption. They also examine what it takes to scale infrastructure, reduce build times, and unlock more abundant industrial capacity in the
- StandardSummaries onlyAI, Growth, and the Future of Healthcare | Anish Acharya & Sachin Jain
Published Jun 10, 2026
SCAN Health Plan CEO Sachin Jain speaks with a16z General Partner Anish Acharya about AI, healthcare, and what it takes for established organizations to adapt during periods of technological change. The conversation explores how AI is reshaping work, customer experience, software development, and organizational structure. Acharya argues that artificial intelligence is not simply another productivity tool, but a fundamentally new technology capable of performing work on behalf of people and organ
- StandardSummaries onlyTyler Cowen & Alex Tabarrok on AI, Jobs, and Economic Growth
Published Jun 9, 2026
Wyatt Thomson of OpenAI speaks with economists Tyler Cowen and Alex Tabarrok about AI, labor markets, and the future of economic growth. The conversation explores one of the most common fears surrounding AI: that increasingly capable systems will eliminate jobs. Cowen and Tabarrok argue instead that economic growth remains the key variable. Throughout history, productivity-enhancing technologies have transformed work, created new industries, and expanded living standards, even as they disrupted
- StandardSummaries onlyBuilding Search for AI Agents with Exa CEO Will Bryk
Published Jun 6, 2026
Sarah Wang speaks with Exa cofounder and CEO Will Bryk about building search infrastructure for the AI era. The conversation covers Exa’s origins, why traditional search engines were not designed for AI agents, and how search changes when the user is no longer a human but an autonomous system. They discuss retrieval, agent workflows, coding agents, data access, and why search may become a foundational layer for the emerging agent economy. Along the way, Bryk shares his views on AI-native product
- StandardSummaries onlyAI Agents and the Fight for Customer Data
Published Jun 5, 2026
Martin Casado speaks with George Fraser, cofounder and CEO of Fivetran, about the future of data infrastructure in the age of AI. The conversation covers Fivetran’s merger with dbt, the changing role of data platforms, and why Fraser believes many companies are overestimating the threat AI poses to enterprise software. They discuss open data access, the backlash against AI agents accessing systems of record, and why businesses still need centralized data foundations even as agent-based workflows
- StandardSummaries onlyAI Eats the World? A Reality Check with Benedict Evans
Published Jun 4, 2026
Benedict EvansErik Torenberg speaks with tech analyst Benedict Evans about the current state of AI, what has changed over the past year, and which questions remain unanswered. The conversation covers coding agents, foundation models, AI infrastructure spending, software economics, and the tension between today's AI excitement and the long-term realities of technology adoption. Evans discusses why coding has emerged as AI's first breakout use case, how previous platform shifts can help frame the current moment
- StandardSummaries onlyBalaji and Steven Glinert on Network States, Supply Chains, and Allied Coalition Strategy
Published Jun 3, 2026
Theo Jaffee and Sophia Puccini speak with Balaji Srinivasan and Steven Glinert about the shifting balance of power between nations, networks, and technology. The conversation covers China’s industrial rise, America’s manufacturing challenges, the role of alliances in a multipolar world, and whether the internet is becoming a political force independent of traditional nation states. They discuss supply chains, technological sovereignty, decentralization, and competing visions for the future globa
- StandardSummaries onlySteven Sinofsky on Apple at 50, Microsoft, and the Future of Computing
Published Jun 2, 2026
Theo Jaffee speaks with Steven Sinofsky about Apple’s 50th anniversary and the evolution of personal computing over the last four decades. Drawing on his experience helping lead Microsoft through the Windows era, Sinofsky reflects on the cultural differences between Apple and Microsoft, the rise of the Mac, the history of Windows, and how product design, hardware integration, and software platforms shaped the modern technology industry. They also discuss the Apple Vision Pro, the new MacBook Neo
- StandardSummaries onlyBuilding AI Agents for Enterprise Operations
Published Jun 1, 2026
Anish Acharya and Olivia Moore speak with Pablo Palafox and Luis Paarup about the challenges of deploying AI agents in operationally complex industries. The conversation covers the evolution of voice AI, enterprise workflows, and why logistics became an early proving ground for agent-based systems. They discuss context, coordination, and execution inside large organizations, as well as the role of forward-deployed engineering, enterprise deployment, and what it takes to move AI from experimentat
- StandardSummaries onlyWhy $1B Exits are Dead
Published May 29, 2026
David George, General Partner at a16z, and David Clark, CIO at VenCap, discuss how AI is reshaping venture capital and the technology industry itself. They examine why today’s AI companies are scaling faster than any previous generation of startups, and why the eventual outcomes may be significantly larger than most investors currently expect. The conversation covers frontier AI models, coding agents, open source competition, data center constraints, and who ultimately captures value in the AI e
- StandardSummaries onlyStablecoins, AI Agents, and The Future of Global Banking
Published May 28, 2026
Angela Strange speaks with Dileep Thazhmon, founder and CEO of Jeeves, about building a global financial operating system for enterprises across Latin America using stablecoins and AI. The conversation covers the challenges of building localized financial infrastructure across 25 countries, from regulation and payments to underwriting and compliance. They also discuss why stablecoin adoption is accelerating in Latin America, and how AI is helping Jeeves scale billions in payment volume while aut
- StandardSummaries onlyMarc Rowan on Private Markets, Software Repricing, and Capital Allocation
Published May 27, 2026
In 1990, Marc Rowan walked out of Drexel with his belongings in a cardboard box. Within a year, Apollo was managing $6 billion. David Haber speaks with Marc Rowan, Cofounder, CEO, and Chair of Apollo Global Management, about building Apollo into one of the world’s largest alternative asset managers and how private capital is reshaping the global economy. The conversation covers the rise of private credit, and why Rowan believes private markets are becoming increasingly central to financing the r
- StandardSummaries onlyRobin Hanson on Prediction Markets, Gambling, and the Future of Forecasting
Published May 26, 2026
Theo Jaffee and Sophia Puccini speak with economist Robin Hanson about prediction markets, gambling, and why he believes speculative markets are one of the most powerful tools humans have for aggregating information and forecasting outcomes. The conversation begins with Minnesota’s recent law criminalizing prediction markets before expanding into the broader backlash surrounding platforms like Kalshi and Polymarket. Hanson explains his long-term vision for “decision markets,” where markets could
- StandardSummaries onlyWhy AI Isn’t Killing SaaS Yet
Published May 25, 2026
Originally aired on MTS segment, Monetary Matters, Jack Farley and Max Wiethe speak with Ara Kharazian, Lead Economist at Ramp, about what real business spending data says about AI adoption, why the “SaaSpocalypse” narrative is overblown, and how companies are actually buying and deploying AI tools. They also discuss Anthropic overtaking OpenAI in Ramp’s AI Index, token-based pricing, AI productivity gains, and why many legacy software firms may be more resilient than people expect. Resources: F
- StandardSummaries onlyHugging Face's Clem Delangue on Open Source AI and the LLM Bubble | MTS Live
Published May 22, 2026
Clem Delangue joins MTS to discuss the global open-source AI landscape, the current large language model bubble, and the future of consumer robotics. Originally aired on MTS, Theo Jaffee and Sofia Puccini speak with Clément Delangue, CEO at Hugging Face, about the global open-source AI race, why he believes the real bubble is in API-based large language models, and how robotics could become the next major interface for AI. They also discuss AI safety, U.S.-China competition, open-weight models,
- StandardSummaries onlyHow Superhuman Took Over Silicon Valley Email
Published May 21, 2026
Rahul Vorra is the founder and CEO of Superhuman, the premium email client for power users. He previously built the Gmail plug-in Reportive and sold it to LinkedIn. He began somewhere unexpected though, as a game designer on RuneScape. In this conversation, Rahul breaks down why most founders misunderstand product market fit, why premium can actually hurt your business, and how deliberate constraint can become your biggest advantage. Follow Rahul Vohra on X: https://x.com/rahulvohra Follow Faree
- StandardSummaries onlyMarc Andreessen on AI, California, and the Future of America | Joe Rogan
Published May 20, 2026
Joe RoganMarc Andreessen joins Joe Rogan for a conversation on AI, politics, technology, and the future of American society. They discuss how artificial intelligence is rapidly moving from novelty to infrastructure, and why Andreessen believes its long-term impact will be overwhelmingly positive despite growing public fear around automation and surveillance. The conversation covers the explosion of AI coding tools, the emergence of “AI agents,” and how these systems are already reshaping software develop
- StandardSummaries onlyRebuilding The American Shipyard
Published May 19, 2026
Erin Price-Wright speaks with Michael Duffey and Dino Mavrookas about what it will take to rebuild the American defense industrial base for a new era of competition. As production capacity becomes a central constraint, they outline how the system must shift toward speed, scale, and modern manufacturing. The conversation covers the role of autonomy in both defense systems and industrial processes, and how new approaches to design, labor, and production can dramatically reduce cost and complexity.
- StandardSummaries onlyThe Plan to Make American Crime Obsolete
Published May 18, 2026
David Ulevitch speaks with Col. Jeffrey Glover and Rahul Sidhu about how AI, drones, and sensor networks are reshaping public safety and what it takes to bring new technology into law enforcement at scale. As departments face staffing shortages, burnout, and rising complexity, they examine how the right tools can make officers more effective, safer, and better supported. The conversation covers how drone-as-first-responder programs are changing the speed and safety of emergency response, from hi
- StandardSummaries onlyVitalik Buterin on Human Agency in the AI Era
Published May 15, 2026
Sophia Dew and Binji Pande speak with Vitalik Buterin about technology, human agency, and how the internet is changing the way people think, build, and relate to the world around them. Drawing from his writings and personal reflections, Buterin discusses how his worldview has evolved over the last decade, from creating Ethereum as a teenager to thinking more deeply about the social and philosophical implications of technology today. The conversation explores the idea of “sanctuary technology,” s
- StandardSummaries onlyBen Horowitz - "Your ONLY job is Right Product, Right Time"
Published May 14, 2026
Ben Horowitz shares lessons from building and scaling companies, drawing on his experience as a founder and CEO. He explains why a founder’s primary responsibility comes down to one thing: delivering the right product at the right time. The conversation covers how strategy actually develops in practice, why a company’s story is inseparable from its strategy, and how founders should think about hiring, fundraising, and decision-making in fast-changing environments. Horowitz also discusses how AI
- StandardSummaries onlyEnergy, Minerals, and the Physical Stack Behind AI
Published May 13, 2026
Erin Price-Wright speaks with Turner Caldwell and Drew Baglino about what it will take to close America's critical minerals gap and modernize the power infrastructure that underpins the AI economy. With the US more than 50 years behind China in critical mineral supply and grid infrastructure built on systems designed a century ago, they examine where the real bottlenecks are and how to move faster. The conversation covers how automation, reinforcement learning, and vertically integrated operatio
- StandardSummaries onlyLloyd Blankfein on Risk, Crisis, and Leadership
Published May 12, 2026
David Haber speaks with Lloyd Blankfein, former CEO of Goldman Sachs, about leadership, risk, and navigating moments of extreme uncertainty. Drawing on his experience leading Goldman through the financial crisis, Blankfein shares how organizations can build resilience, make decisions under pressure, and maintain culture while scaling. They discuss the importance of risk management as both a discipline and a mindset, the difference between being wrong and being reckless, and how great organizatio
- StandardSummaries onlyMarc Andreessen on Builder Culture in the Age of AI
Published May 11, 2026
Erik Torenberg speaks with Marc Andreessen about the state of AI, media, and the broader cultural and economic shifts shaping the internet. They discuss how narratives around AI, from fear to hype, are influencing public perception, and why real-world usage tells a very different story. The conversation covers AI’s impact on jobs and productivity, the rise of “AI-native” builders, and why increased capability tends to expand work rather than eliminate it. Andreessen also examines how companies a
- StandardSummaries onlyBen Horowitz on the Next Technology Era
Published May 8, 2026
David Ulevitch speaks with Ben Horowitz about what it means to lead the technology industry at scale, and the responsibilities that come with it. Following the firm’s largest-ever fundraise, they discuss how venture capital, technology, and national strategy are increasingly intertwined. The conversation covers America’s role in the next technological revolution, from AI to advanced manufacturing, and why maintaining technological leadership is critical not just for economic growth, but for glob
- StandardSummaries onlyCrypto Fund 5: We Raised $2.2B. Here’s Why.
Published May 7, 2026
Robert Hackett speaks with the general partners at a16z crypto about the launch of their fifth crypto fund and the current state of the industry. They reflect on how crypto has evolved from an ideological movement into a more pragmatic, product-focused ecosystem, shaped by real-world use cases and increasing regulatory clarity. The conversation covers the rise of stablecoins, onchain finance, and new market infrastructure, as well as the growing overlap between crypto and AI. The group also disc
- StandardSummaries onlyThe New Space Race: NASA, Artemis, and the Race to the Moon
Published May 6, 2026
The New Space RaceMorgan Brennan speaks with NASA Administrator Jared Isaacman about the next phase of American space exploration and the urgency behind returning to the moon. They discuss the Artemis program, the challenges of cost, speed, and execution, and how a new competitive landscape is reshaping NASA’s priorities. The conversation covers the role of public-private partnerships, the rise of commercial space companies, and the need to rebuild core capabilities within NASA. Isaacman also outlines how the age
- StandardSummaries onlyBuilding Blackstone, Backing Costco, with Tony James
Published May 5, 2026
Tony JamesDavid Haber speaks with Tony James about building enduring firms across multiple eras of finance. From joining DLJ when it was a subscale firm to helping grow Blackstone into one of the largest asset managers in the world, James reflects on the decisions, structures, and cultural principles that enabled long-term success. They discuss the origins of leveraged buyouts, the evolution of private markets, and how identifying structural opportunities early can create lasting competitive advantage. Ja
- StandardSummaries onlySarah Rogers: Free Speech, AI Diplomacy, and What America Owes Its Allies
Published May 4, 2026
Sarah RogersKatherine Boyle speaks with Sarah Rogers, Under Secretary for Public Diplomacy, about the intersection of AI, free speech, and global information systems. They discuss how major technological shifts, from the printing press to the internet to AI, have reshaped communication and power, and why this moment may be even more consequential. Recorded at the a16z American Dynamism Summit, the conversation explores the role of public diplomacy in the digital age, the risks of censorship and overregulati
- StandardSummaries onlyBalaji and Taylor Lorenz on AI and Media
Published May 1, 2026
Theo Jaffee speaks with Balaji Srinivasan and Taylor Lorenz about how AI is reshaping media, trust, and online communication. Building on prior public disagreements between the two, the conversation revisits core tensions around media, technology, and power in a rapidly changing information environment. They discuss the breakdown of traditional information systems, the rise of AI-generated content, and why new models for verifying identity and truth may be necessary. The conversation lays out co
- StandardSummaries onlyWorkday’s Last Workday? AI and the Future of Enterprise Software
Published Apr 30, 2026
Elena Burger speaks with Joe Schmidt, partner on the enterprise team at a16z, about the future of enterprise software in the age of AI. Using Workday as a case study, they discuss why many of today’s most important enterprise systems feel broken, how platform shifts reshape entire categories, and what an AI-native replacement might look like. The conversation covers the limits of legacy SaaS, why “AI revenue” may be overstated, and how agents could fundamentally change how companies manage workf
- StandardSummaries onlyThe Shift in Global Drug Development
Published Apr 29, 2026
Theo Jaffee and Gabriel Dickinson speak with Cremieux about China’s rapid rise to the top of global clinical trial output. They discuss the regulatory reforms that accelerated China’s progress, the surge in novel drug development, and what the US would need to change to stay competitive in biomedical innovation. Resources: Follow Cremieux on X: https://x.com/cremieuxrecueil Follow Theo on X: https://x.com/theojaffee Follow Gabriel on X: https://x.com/gbrl_dick Stay Updated:Find a16z on YouTube:
- StandardSummaries onlyJohn and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software
Published Apr 28, 2026
This interview with Stripe cofounders John and Patrick Collison originally aired on TBPN. They discuss Stripe's 34% growth and new employee tender offer, how agent commerce and stablecoins may require high-throughput blockchains built for millions of transactions per second, and why the economics of software are shifting from mass-produced products to bespoke, on-demand systems cooked fresh at the moment of use. Resources: Follow TBPN on Twitter: https://x.com/tbpn Follow Patrick Collison on Twi
- StandardSummaries onlyBen Horowitz on Venture Capital and AI
Published Apr 27, 2026
Anjney Midha, founder of AMP PBC, speaks with Ben Horowitz, cofounder of a16z, about how venture capital changed from a small, relationship-driven business into a scalable system for backing new technology companies. They discuss network effects, firm design, leadership, culture, and how AI is reshaping both the capital race and the kinds of companies that can be built now. Resources: Follow Ben on X: https://x.com/bhorowitz Follow Anjney on X: https://x.com/AnjneyMidha Watch more from CS 153: F
- StandardSummaries onlyAI Inside the Enterprise
Published Apr 24, 2026
Steven Sinofsky, board partner at a16z, Aaron Levie, CEO of Box, and Martin Casado, general partner at a16z, discuss the reality of AI inside enterprises. They cover the gap between Silicon Valley and the rest of the world, why most AI initiatives fail in large organizations, and how agents, infrastructure, and workflows are evolving beyond the hype. Resources: Follow Aaron Levie on X: https://twitter.com/levie Follow Steve Sinofsky on X: https://twitter.com/stevesi Follow Martin Casado on X: ht
- StandardSummaries onlyMartin Shkreli on AI, Pharma, and What Actually Matters
Published Apr 23, 2026
Erik Torenberg speaks with Martin Shkreli, American investor and businessman, about how he sees the AI landscape, from OpenAI to Anthropic, and what actually matters beyond the hype. They also talk through the future of computing, the limits of “vibe coding,” and why biotech and pharma remain some of the toughest industries to get right. Resources: Follow Martin on X: https://x.com/MartinShkreli Stay Updated:Find a16z on YouTube: YouTubeFind a16z on XFind a16z on LinkedInListen to the a16z Show
- StandardSummaries onlyBalaji Srinivasan: Prove Correct, Not Just Go Direct
Published Apr 22, 2026
Balaji SrinivasanErik Torenberg and Theo Jaffee speak with Balaji Srinivasan, angel investor, entrepreneur, and author of The Network State, about how AI is transforming media, eroding trust, and reshaping how information is created and verified. They discuss why systems like hiring, journalism, and online communication are breaking under synthetic content, and what replaces them. The conversation also examines the role of cryptography, on-chain data, and new models of proof in rebuilding trust online. Resources
- StandardSummaries onlyMarc Andreessen: Monitoring the Situation and the Future of Media
Published Apr 21, 2026
Marc AndreessenErik Torenberg and Theo Jaffee speak with Marc Andreessen, cofounder and general partner at a16z, about the launch of Monitoring the Situation (MTS), a new, always-on media network on X. They discuss the rise of the “current thing,” how narratives spread in real time, and why internet-native media is reshaping politics, culture, and attention. Resources: Follow Marc X: https://x.com/pmarca Follow Eric on X: https://x.com/eriktorenberg Follow Theo on X: https://x.com/theojaffee Follow MTS on X: h
- StandardSummaries onlyRethinking Git for the Age of Coding Agents with GitHub Cofounder Scott Chacon
Published Apr 20, 2026
Matt Bornstein speaks with Scott Chacon, cofounder of GitHub and CEO of GitButler, about why Git's user interface has barely changed since 2005, how GitButler is rethinking version control for both humans and AI agents, and what the "next GitHub" might actually look like. They cover parallel branches, agent-optimized CLI design, the future of code review, and why the best engineers of the future will be the best writers. Resources: Follow Scott Chacon on X: https://twitter.com/chacon Follow Matt
- StandardSummaries onlyNetwork Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show
Published Apr 19, 2026
This episode originally aired on The Kevin Rose Show. Kevin Rose speaks with Anish Acharya, general partner at a16z, about how AI is rewriting the rules of consumer software, the defensibility of network effects in a world where anyone can spin up an app in 48 hours, and why the real threat to consumer founders may be the cost of inference, not competition. They also discuss model pricing, the future of the four-day work week, and peptides. Resources: Follow Anish on X: https://x.com/illscience
- StandardSummaries onlyFrom Models to Mobility: Building Waymo with Dmitri Dolgov
Published Apr 17, 2026
Dmitri DolgovWaymo is now delivering hundreds of thousands of fully autonomous rides each week — but getting there required more than better models. It meant building a complete system for training, evaluating, and deploying a driver in the real world. In this episode — originally aired on the Cheeky Pint podcast — Waymo Co-CEO Dmitri Dolgov joins John Collison to break down how self-driving actually works today: from sensor fusion across LiDAR, radar, and cameras, to simulation, “critic” models, and the rol
- StandardSummaries onlyTechnology, Culture, and the Next AI Interface with signüll
Published Apr 16, 2026
Erik Torenberg and Anish Acharya, general partners at a16z, speak with signüll about how technology reshapes culture, relationships, and the products we build. The conversation covers tacit knowledge versus intellectual knowledge, dating apps and their effect on human connection, AI relationships, why Claude feels artisan while other models feel utilitarian, and what consumer founders should actually care about. Resources: Follow signüll on X: https://twitter.com/signulll Follow Anish Acharya on
- StandardSummaries onlyReplit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI
Published Apr 15, 2026
Jack Neel speaks with Amjad Masad, CEO at Replit, about how AI is making it easier than ever to build and ship software without a technical background. They discuss Replit's rise from a browser-based coding tool to a platform generating $250 million in annual revenue, why Masad turned down a $1 billion acquisition offer, and his case for why AI represents empowerment rather than existential risk. This episode originally aired on The Jack Neel Podcast. Follow Amjad Masad on X: https://twitter.com